Pipeline

In order to demonstrate the diversity of the AMR-dedicated SMEs’ pipeline in Europe, the BEAM Alliance has collated its members’ technological assets into a comprehensive portfolio. While its size is already impressive, the proposed categorization approach is further revealing the high level of innovativeness that is being deployed, both at clinical and preclinical stages.

BEAM Infection Curve (BIC)

BEAM Infection Curve (BIC)

Pipeline Rx

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memberproductbic*typetargets/indicationsdevelopment
stage
NanoRevivStaph-EX3aOtherBone & Joint InfectionsPre-clinical
PHAXIAMPHAXIAM NA3aPhage Diabetic foot ulcer with anti S.aureus phage therapy Pre-clinical
PHAXIAMPHAXIAM NA3aPhageHospital acquired or ventilator- acquired bacterial pneumoniae with anti-P.aeruginosa Phage therapy Pre-clinical
PHAXIAMPP970, PP1002, PP1151, PP20003aPhageComplicated Urinary Tract Infection (cUTI) with anti-E. coli phage therapyIND/CTA ready
PHAXIAMPP1493/PP18153aPhageEndocarditis with anti-S.aureus phage therapy Phase I
PHAXIAMPP1493/PP18153aPhageProsthetic Joint Infection (PJI) with anti-S.aureus phage therapy Phase II
TechInvention Lifecare Pvt LtdAcinolysin3aProtein/PeptideAcinetobacter baumannii / Healthcare associated infections such as bacteremia, pneumonia, meningitis, urinary tract infectionsDiscovery
TechInvention Lifecare Pvt LtdKlebsiLysin3aProtein/PeptideKlebsiella Pneumoniae / Pneumonia and other Healthcare associated infectionsDiscovery
TechInvention Lifecare Pvt LtdEcoLysin3aProtein/PeptideUropathogenic Escherichia coli / Urinary tract infectionLead opt
discoveric bio betaNIDB-3002AntibodyNon-cystic fibrosis bronchiectasisLead opt
discoveric bio betaNIDB-3001AntibodyBloodstream infectionsLead opt
Omnix MedicalOMN703a/5aProtein/PeptideP. aeruginosa; Escherichia coli; K. pneumoniae; E. faceum / Acne or Atopic-DermatitisLead opt
Omnix MedicalOMN513a/5aProtein/PeptideP. aeruginosa; Escherichia coli; K. pneumoniae; E. faceum; S. aureus; B. oleronius / Cystic Fibrosis (CF)Lead opt
VibioSphenTherapeptics3aProtein/PeptideA. baumannii; P. aeruginosa; Klebsiella pneumoniae; Staphylococcus aureus; Clostridioides difficile/Intra-abdominal infections (cIAI)Lead opt
Mileutis Ltd.Peptide(s) hydrolyzed from caseinProtein/PeptideP. aeruginosa; Enterobacter spp.; Salmonella sppPre-clinical
Helperby Therapeutics LtdHY-007 Infusion3d/5aOtherAcinetobacter baumannii/Lung, blood. CNS and skin/soft tissue structure infectionsLead opt
Helperby Therapeutics LtdHY-001 Infusion3d/5aOtherEscherichia coli, Klebsiella spp/Intra-abdominal infections Phase I
Phico Therapeutics LtdSASPject™ PT93aPhageS. aureus/Animal HealthLead opt
Phico Therapeutics LtdSASPject™ PT83aPhageS. aureus/BacteraemiaLead opt
Phico Therapeutics LtdSASPject™ PT3.93aPhageP. aeruginosa/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Pre-clinical
BasileaNovel target (IspF inhibitor)3aNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales / Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Discovery
BasileaNovel target (DXR inhibitor)3aNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales / Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Lead opt
BasileaNovel class3aNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales / Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Lead opt
BasileaNovel class3aNMEAspergillus spp; Mucorales; Fusarium spp; Scedosporium spp; Cryptococcus spp; Candida spp / Invasive fungal diseaseLead opt
Destiny Pharma plcXF-731bNMEStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae / Prevention of oral mucositisPre-clinical
Destiny Pharma plcXF-733aNMEStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae / BurnsPre-clinical
Destiny Pharma plcXF-733aNMEStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae / Treatment of chronic rhinosinusitisPre-clinical
Destiny Pharma plcXF-733aNMEStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae / Cystic fibrosis associated infectionsPre-clinical
Destiny Pharma plcXF-733aNMEStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae / Prevention of post-surgical infectionPhase II
Destiny Pharma plcNTCD-M31bNMEToxigenic strains of C. difficile / Prevention of recurrence of C diff infectionPhase II
Destiny Pharma plcSPOR-COV1aNMERespiratory viruses, SARS-COV-2 & Influenza / Prevention of viral respiratory infectionsPre-clinical
Infex Therapeutics LtdRESP-X3cAntibodyP. aeruginosa / Non-cystic-fibrosis bronchiectasisPhase I
Infex Therapeutics LtdMET-X3dNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp. / Complicated urinary tract infections (cUTI), HAP, VAP, bloodstream infections, intra-abdominal infectionsPre-clinical
Infex Therapeutics LtdCOV-X-OtherPan-coronavirus / Coronavirus infectionsLead opt
Infex Therapeutics LtdRDX-023aNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp. / Gram-negative AMR infectionsDiscovery
Infex Therapeutics LtdPAN-X-OtherPan-coronavirus / Coronavirus infectionsDiscovery
AdjuTec Pharma ASAPC2473dNMEEscherichia coli; Klebsiella pneumoniae / complicated urinary tract infections (cUTI)Pre-clinical
Ultupharma ABULT23aNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Salmonella spp; Shigella spp.; Helicobacter pylori; Haemophilus influenzae; Staphylococcus aureus; Streptococcus pneumoniae / Bloodstream infectionsPre-clinical
Ultupharma ABULT33aProtein/PeptideA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Staphylococcus aureus / Bloodstream infectionsLead opt
VAXDYNKapaVax1aVaccineKlebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii/Community acquired pneumonia (CAP) and other upper respiratory infections (URTI) (sinusitis/otitis media etc)Pre-clinical
Spexis AGLptA-OMPTA3aProtein/PeptideEscherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp. / HABP/VABP, cUTI, cIAILead opt
F2G LtdOlorofim3aNMEDHODH inhibitor/Aspergillosis refractory, resistant or intolerant; Lomentospora prolificans, Scedosporium, Fusarium and Scopulariopsis species; Coccidioidomycosis refractoryPhase III
AdjuTec Pharma ASAPC1483dNMEKlebsiella pneumoniae; Enterobacter spp / complicated urinary tract infections (cUTI)IND/CTA ready
Aptorum Group LtdALS-33dOtherStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae//Treatment of gram+ve bacterial infectionsLead opt
Aptorum Group LtdALS-24aOtherStaphylococcus aureus; Enterococcus faecium; Streptococcus pneumoniae/Treatment of gram+ve bacterial infectionsLead opt
Aptorum Group LtdALS-13aOtherInfluenza virus A//Treatment of viral infectionsLead opt
Aptorum Group LtdALS-43cOtherS. aureus//Treatment of bacterial infectionsPhase I
Debiopharm InternationalDebio 1454/S3aNMEA. baumannii/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Lead opt
OLGRAMOl20-015aProtein/PeptideP. aeruginosa; Broad-spectrum G+/G-/Cystic fibrosis associated infectionsPre-clinical
Selmod GmbHslm 5003aNMEEscherichia coli; Broad-spectrum G+/G-/Complicated urinary tract infections (cUTI)Pre-clinical
Selmod GmbHslm 4003aNMEA. baumannii; Broad-spectrum G+/G-/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Pre-clinical
Selmod GmbHslm 3003aNMEKlebsiella pneumoniae; Broad-spectrum G+/G-/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Pre-clinical
Selmod GmbHslm 2003aProtein/PeptideCandida albicans, Aspergillus fumigatus, Candida auris/Invasive aspergillosis, Oral Candidiasis, Bronchopulmonary aspergillosisLead opt
Selmod GmbHslm 1003aNMECandida albicans, Aspergillus fumigatus, Candida auris/Invasive aspergillosis, Oral Candidiasis, Bronchopulmonary aspergillosisLead opt
BioNTech R&DPM-4773aProtein/PeptideGardnerella/Bacterial vaginosisPre-clinical
AiCuris Anti-infective Cures AGNPI Scaffolds3aNMEUndisclosed/Healthcare-asscoiated infectionsLead opt
AiCuris Anti-infective Cures AGMacrocyles3aNMEUndisclosedLead opt
Assuré Medical LimitedSol-UTI1bOtherP. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Proteus spp.; Staphylococcus aureus / Uncomplicated urinary tract infections (uUTI)Pre-clinical
BioVersys AGBV1003aNMEA. baumannii/HAP, VAP, BSIPhase I
AlphanososW5P1 + WXPYY (more potent lead)OtherN. gonorrhoeae; S. aureus/GonorrhoeaIND/CTA ready
ABAC therapeuticsABAC-402443aNMEStaphylococcus aureus/Hospital infectionsLead opt
ABAC therapeuticsABAC-404113aNMEStreptococcus pneumoniae/Community acquired pneumonia (CAP) and other upper respiratory infections (URTI) (sinusitis/otitis media etc)Lead opt
ANTABIO S.A.SSBLi (ANT3310)3dNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales; Haemophilus influenzae / Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP) IND/CTA ready
VibioSphenSativa3bNMEP. aeruginosaPre-clinical
VAXDYNAcinetoVax1aVaccineAcinetobacter baumannii/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Pre-clinical
QureTech Bio ABTIB3aNMEC. trachomatis / Ocular Chlamydia infectionLead opt
QureTech Bio ABGmP3dNMEStaphylococcus aureus; Enterococcus faecium; Clostridioides difficile; E. faecalis; S. epidermidis / Complicated urinary tract infections (cUTI)Lead opt
QureTech Bio ABCIB3aNMEC. trachomatis / Genital Chlamydia infectionLead opt
QureTech Bio ABMTI3dNMEMycobacterium tuberculosis / TuberculosisLead opt
Spexis AGMurepavadin (inhaled)3aProtein/PeptideP. aeruginosa / Cystic fibrosis associated infectionsPhase I
Spexis AGColiFin®3aProtein/PeptideA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae / Cystic fibrosis associated infectionsPhase III
Omnix MedicalOMN63a/5aProtein/PeptideA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Phase I
NosopharmNOSO-2G3aNME A. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Lead opt
NosopharmNOSO-5023aNME Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales; Staphylococcus aureus/Complicated urinary tract infections (cUTI)IND/CTA ready
Northern Antibiotics Oy (Ltd)NAB8153aProtein/PeptideA. baumannii; Enterobacter spp./Complicated urinary tract infections (cUTI)Lead opt
Northern Antibiotics Oy (Ltd)NAB7393aProtein/PeptideA. baumannii; Enterobacter spp./Complicated urinary tract infections (cUTI)Lead opt
Mutabilis SAS2G-Dabocin3aNMEEnterobacterales, P. aeruginosa, A. baumannii/Complicated urinary tract infections (cUTI)Lead opt
Mutabilis SASEBL-14633aNMEEnterobacterales/Complicated urinary tract infections (cUTI)Pre-clinical
IMMUNETHEP, SAUnimab3cAntibodyEscherichia coli; Klebsiella pneumoniae; Staphylococcus aureus; Streptococcus pneumoniae; S. agalactiae/Bloodstream infectionsPre-clinical
IMMUNETHEP, SAPNV1aVaccineS. aureus, E. Coli, ETEC/Bloodstream infections, Community acquired pneumonia (CAP) and other upper respiratory infections (URTI) (sinusitis/otitis media etc)Pre-clinical
Hypharm GmbHHY-1331bPhageStaphylococcus aureus/Nasal colonization with MRSAIND/CTA ready
Helperby Therapeutics LtdHY-001 Infusion3d/5aOtherEscherichia coli, Klebsiella spp/Complicated urinary tract infections (cUTI)Phase II
Helperby Therapeutics LtdHY-003 Infusion3d/5aOtherEscherichia coli, Klebsiella spp/Skin/soft tissue structure, lung, blood and CNS infectionsPre-clinical
Helperby Therapeutics LtdHY-004 Inhalation3d/5a/1dOtherP. aeruginosa; Staphylococcus aureus including MRSA/Cystic fibrosis associated infectionsPre-clinical
Helperby Therapeutics LtdHY-005 Infusion3d/5aOtherP. aeruginosa; Staphylococcus aureus including MRSA/Lung, blood. CNS and skin/soft tissue structure infectionsLead opt
Eligo BioscienceEB0041bPhageEscherichia coli; Klebsiella pneumoniae/Bloodstream infectionsPre-clinical
Debiopharm InternationalDebio 14533aNMENeisseria gonorrhoeae/GonorrhoeaPre-clinical
Debiopharm InternationalAfabicin3aNMEStaphylococcus spp./ABSSSI (caused by S. aureus), bone and joint infectionsPhase II
Combioxin SACAL024aOtherVirulence factors, broad spectrum Gram+ and Gram-, resistance agnostic/Severe community-acquired bacterial pneumoniaPhase II
Centauri Therapeutics LtdABX013cOtherA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp./Healthcare-asscoiated infectionsPre-clinical
Centauri Therapeutics LtdABX023cOtherP. aeruginosa/Healthcare-asscoiated infectionsPre-clinical
BioVersys AGBV2004aNMEStaphylococcus aureus/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Lead opt
BioVersys AGBV3003aNMEA. baumannii; P. aeruginosa; Enterobacter spp.; Staphylococcus aureus; Enterococcus faecium/Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)Lead opt
BioVersys AGBVL-GSK0983dNMEM. tuberculosis/TuberculosisPhase I
BasileaCeftobiprole3aNMES. aureus (including MRSA); Streptococcus spp; Enterococcus faecalis; Enterobacterales; P. aeruginosa / Staphylococcus aureus bacteremia; Acute bacterial skin and skin structure infectionsPhase III
BasileaCeftobiprole3aNMES. aureus (including MRSA); Streptococcus spp; Enterococcus faecalis; Enterobacterales; P. aeruginosa; Haemophilus influenzae / CAP, HAPMarketed
ANTABIO S.A.SPEi (ANT3273)3c/1b/4a/4bNMEP. aeruginosa / Non-CF bronchiectasis associated infectionsPre-clinical
ANTABIO S.A.SMBLi (ANT2681)3dNMEEscherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Proteus spp.; Salmonella spp; Shigella spp.; Other Enterobacterales; Haemophilus influenzae / Complicated urinary tract infections (cUTI)IND/CTA ready
AlphanososW16P05763eOtherA. baumannii, P. aeruginosa, MRSA,N. gonorrhoeae, M. tuberculosis/Infectious skin conditions (eczema, acne, sporiasis, ...), difficult woundsPre-clinical
ALLECRA THERAPEUTICSCefepime / Enmetazobactam3dNMEcUTI, APPhase III
AktheliaAKT-0113cNMEEscherichia coli; Salmonella spp; Broad-spectrum G+/G-/GI infectionsLead opt
AiCuris Anti-infective Cures AGArtilysins3aProtein/PeptideUndisclosed/Bloodstream infections, Diabetic foot infectionLead opt
AGILeBiotics B.V.ABX-3953aNMEHospital-treated MDR Gram-negative infectionsLead opt
AGILeBiotics B.V.ABX-605 (Maranmicin)3aNMEA. baumannii; P. aeruginosa; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; Citrobacter spp.; Staphylococcus aureus; Enterococcus faecium; Mycobacterium Avium Complex; Mycobacterium Abscessus/Cystic fibrosis associated infections - NTMPre-clinical
ABAC therapeuticsABAC-398773aNMEA. baumannii/Hospital infectionsPre-clinical
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*BIC: BEAM Infection Curve

The displayed information are not necessarily reflecting the official current position of each BEAM members; please refer to each company’s website for updated information, or contact them directly.

Pipeline Dx

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memberkit/testtargeted resultpathogens/indicationslab workflowdevelopment stage
NosticsDUTIPathogen IDMultiplex bacteria
Urinary Tract infections		From urine
Surface Enhanced Raman Spectroscopy
<30 minutes		Feasibility Phase
MolsidfMicRapid antimicrobial susceptibility testAll
AST		From isolated colony
Proprietary reader
<4h		Feasibility Phase
MolsidPythia UTIAMR Mechanism of Resistance IDAll
From urine
Microplate-reader
<2h		Development Phase
MolsidPythia StaphAMR Mechanism of Resistance IDS. aureus
From isolated colony
Microplate-reader
<2h		Development Phase
NG BiotechNG-Test Blood Culture PrepAMR Mechanism of Resistance IDEnterobacteriaceae /
Rapid and Direct detection of the major groups of carbapenemases		From isolated colony
LFIA
<30 minutes		CE-IVD and/or FDA 510k
NG BiotechNG-Test MCR-1AMR Mechanism of Resistance IDEnterobacteriaceae /
Detection of colistine resistance		From isolated colony
LFIA
<30 minutes		CE-IVD and/or FDA 510k
NG BiotechNG-Test CTX-M MULTIAMR Mechanism of Resistance IDEnterobacteriaceae /
Detection of the 5 most prevalent ESBL CTX-M Groups (1, 2, 8, 9 and 25)		From isolated colony
LFIA
<30 minutes		CE-IVD and/or FDA 510k
NG BiotechNG-Test CARBA 5AMR Mechanism of Resistance IDEnterobacteriaceae, carbapenem-resistant; 3rd generation cephalosporin-resistant; A. baumannii, carbapenem-resistant; P. aeruginosa, carbapenem-resistant /
Detection and differentiation of KPC, OXA-48, VIM, IMP and NDM		From PBS + Isolated colony
LFIA
<30 minutes		CE-IVD and/or FDA 510k
MeMed Diagnostics Ltd.MeMed COVID-19 Severity™Likelihood of meeting severe outcomePoint-of-need aid to the clinician's stratification of COVID-19 disease severityFrom serum/plasma
 
<30 minutes		CE-IVD and/or FDA 510k
MeMed Diagnostics Ltd.MeMed BV®Viral vs BacterialPoint-of-need aid to the clinician's discrimination of the viral/bacterial nature of an infectionFrom serum/plasma
 
<30 minutes		CE-IVD and/or FDA 510k
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The displayed information are not necessarily reflecting the official current position of each BEAM members; please refer to each company’s website for updated information, or contact them directly.