Pipeline

In order to demonstrate the diversity of the AMR-dedicated SMEs’ pipeline in Europe, the BEAM Alliance has collated its members’ technological assets into a comprehensive portfolio. While its size is already impressive, the proposed categorization approach is further revealing the high level of innovativeness that is being deployed, both at clinical and preclinical stages.

Pipeline Rx

Click on column headers to sort the table

memberproductbictypetargetinnovation
criteria		development
stage
VAXDYNKAPAVAX (VXD-005)1aVaccinePrecise Pathogen ID
Priority Pathogen *
Community acquired pneumonia (CAP) and other upper respiratory infections (URTI) (sinusitis/otitis media etc)		New Class
New Target
New MoA		Pre-clinical
Spexis AGLptA-OMPTA3aProtein/PeptideGram -
Priority Pathogen *
Complicated urinary tract infections (cUTI)		New Class
New Target
New MoA		Lead opt
F2G LtdOlorofim3aNMEPrecise Pathogen ID
 
Aspergillosis refractory, resistant or intolerant to currently available therapy. Infections due to Lomentospora prolificans, Scedosporium, Fusarium and Scopulariopsis species. Treatment of coccidioidomycosis refractory or otherwise unable to be treated with standard of care therapy. 		New Class
New Target		Phase II
AdjuTec Pharma ASAPC1483dNMEGram -
Priority Pathogen *
MBL-CRE		New Class
New MoA		Pre-clinical
Diotheris SASDECOLONIZE1bOtherPrecise Pathogen ID
Priority Pathogen *
Decolonization of S.aureus MR		New Class
New Target
New MoA		Discovery
Diotheris SASPREVENT1bOtherPrecise Pathogen ID
Priority Pathogen *
Prevent infection by S.aureus MR		New Class
New Target
New MoA		Pre-clinical
Aptorum Group LtdALS-33dOtherGram +
Priority Pathogen *
Reviving existing antibiotics to overcome drug Resistance		New Class
New Target
New MoA		Lead opt
Aptorum Group LtdALS-24aOtherGram +
Priority Pathogen *
Treatment of bacterial infections casued by Gram Positive Bacteria including Staphylococcus aureus (MRSA)		New Class
New Target
New MoA		Lead opt
Aptorum Group LtdALS-13aOtherPrecise Pathogen ID
Priority Pathogen *
Treatment of viral infections casued by influenza virus A		New Class
New Target
New MoA		Lead opt
Aptorum Group LtdALS-43cOtherPrecise Pathogen ID
Priority Pathogen *
Treatment of bacterial infections casued by Staphylococcus aureus infections including MRSA		New Class
New Target
New MoA		Pre-clinical
Debiopharm International1454/S3aNMEGram -
Priority Pathogen *
Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)		New Class
New Target
New MoA		Lead opt
OLGRAMOl20-01Protein/PeptideBroad Gram +/-
Priority Pathogen *
Infectious relapses 		New Class
New MoA		Pre-clinical
Selmod GmbHslm 5003aNMEBroad Gram +/-
Priority Pathogen *
 		New Class
New Target
New MoA		Pre-clinical
Selmod GmbHslm 4003aNMEGram -
Priority Pathogen *
 		New Class
New Target
New MoA		Discovery
Selmod GmbHslm 3003aNMEGram -
Priority Pathogen *
 		New Class
New Target
New MoA		Discovery
Selmod GmbHslm 2003aNMEPrecise Pathogen ID
Priority Pathogen *
C.C. albicans, flucanozole-resistant; Drug-resistant Aspergillus; Drug-resistant C. auris		New MoALead opt
Selmod GmbHslm 1003aNMEPrecise Pathogen ID
Priority Pathogen *
C. albicans, flucanozole-resistant; Drug-resistant Aspergillus; Drug-resistant C. auris		New Class
New Target
New MoA		Lead opt
BioNTech R&DPM-4773aProtein/PeptidePrecise Pathogen ID
 
Endolysin specific to bacteria of the genus Gardnerella to treat Bacterial Vaginosis		New TargetLead opt
Nabriva Therapeutics GmbHBC-21263aNMEGram -
Priority Pathogen *
Respiratory tract infections caused by P. aeruginosa, A. baumannii and Burkholderia cepacia complex		New Class
New MoA		Pre-clinical
Nabriva Therapeutics GmbHBC-70133aNMEBroad Gram +/-
Priority Pathogen *
Topical treatment of skin and skin structure infections		Phase I
Destiny Pharma plcXF-733aNMEBroad Gram +/-
Priority Pathogen *
Dermal wound infections		New Class
New Target
New MoA		Phase I
AiCuris Anti-infective Cures AGNPI Scaffolds3aNMEGram -
Priority Pathogen *
Undisclosed		New Class
New Target
New MoA		Discovery
AiCuris Anti-infective Cures AGMacrocyles3aNMEGram -
Priority Pathogen *
Undisclosed		New Class
New Target
New MoA		Discovery
Basileaundisclosed3aNMEGram -
Priority Pathogen *
Serious infections in hospitalized patients 		New ClassLead opt
BasileaNon beta-lactam PBP inhibitor3aNMEGram -
Priority Pathogen *
Serious infections in hospitalized patients 		New ClassLead opt
Pherecydes PharmaPP11513aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Escherichia coli		New Class
New MoA		Pre-clinical
Pherecydes PharmaPP10023aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Escherichia coli		New Class
New MoA		Pre-clinical
Pherecydes PharmaPP9703aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Escherichia coli		New Class
New MoA		Pre-clinical
Pherecydes PharmaPP9543aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Escherichia coli		New Class
New MoA		Pre-clinical
Pherecydes PharmaPP8143aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Escherichia coli		New Class
New MoA		Pre-clinical
Pherecydes PharmaPP7003aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Escherichia coli		New Class
New MoA		Pre-clinical
Assuré Medical LimitedSol-UTI1bOtherGram -
Priority Pathogen *
Recurrent Urinary Tract Infection (rUTI)		New Target
New MoA		Pre-clinical
BioVersys AGBV1003aNMEGram -
Priority Pathogen *
A. baumannii (HAP,VAP, BSI)		New MoAPhase I
Madam Therapeutics BVP103aProtein/PeptideBroad Gram +/-
Priority Pathogen *
Veterinary Diseases (companion animals and lifestock)		New Class
New Target
New MoA		Pre-clinical
Destiny Pharma plcDPD-2073aNMEGram +
Priority Pathogen *
MDR bacterial eye infections		New Class
New Target
New MoA		Pre-clinical
AlphanososW9P1543eOtherPrecise Pathogen ID
Priority Pathogen *
Tuberculosis, Buruli Ulcer		New Class
New Target
New MoA		Lead opt
ABAC therapeuticsABAC-40,2443aNMEPrecise Pathogen ID
Priority Pathogen *
Infections by MDR/XDR Staph aureus		New Class
New Target
New MoA		Lead opt
ABAC therapeuticsABAC-401053aNMEGram -
Priority Pathogen *
Infections by MDR/XDR A baumannii, including ColistinR and CarbapenemR		New Class
New Target
New MoA		Lead opt
ANTABIO S.A.SANT33103dNMEGram -
Priority Pathogen *
Hospital-acquired infections caused by carbapenem-resistant Enterobacteriaceae (CRE) and Acinetobacter [cUTI, cIAI, Nosocomial Pneumonia]		New MoAPre-clinical
VibioSphenSativa3bNME 
 
Pulmonary infection, UTI		Pre-clinical
VAXDYNACINETOVAX (VXD-001)1aVaccinePrecise Pathogen ID
Priority Pathogen *
Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)		New Class
New Target
New MoA		Pre-clinical
Summit Therapeutics plcSMT0265713aNMEGram -
Priority Pathogen *
Gonorrhoea infection		New Class
New Target
New MoA		Pre-clinical
Summit Therapeutics plcRidinilazole3aNMEGram +
Priority Pathogen *
Clostridium difficile infection		New Class
New Target
New MoA		Phase III
QureTech Bio ABTIB3aNMEPrecise Pathogen ID
 
Trachoma, Chlamydia eye infection		New Class
New Target
New MoA		Lead opt
QureTech Bio ABGmP3dNMEGram +
Priority Pathogen *
VRE and MRSA		New Class
New Target
New MoA		Lead opt
QureTech Bio ABCIB3aNMEPrecise Pathogen ID
Priority Pathogen *
Genital Chlamydia infection		New Class
New Target
New MoA		Lead opt
QureTech Bio ABMTI3dNMEPrecise Pathogen ID
Priority Pathogen *
MDR Tuberculosis		New Class
New Target
New MoA		Pre-clinical
Spexis AGMurepavadin (inhaled)3aProtein/PeptideGram -
Priority Pathogen *
Cystic fibrosis associated infections		New Class
New Target
New MoA		IND/CTA ready
Spexis AGBamA-OMPTA3aProtein/PeptideGram -
Priority Pathogen *
Hospitalacquired or Ventilatoracquired bacterial pneumoniae (HABP/VABP)		New Class
New Target
New MoA		Lead opt
Phico Therapeutics LtdSASPject™ PT43aOtherPrecise Pathogen ID
Priority Pathogen *
Serious Klebsiella Pneumoniae infections where treatment options are limited		New Target
New MoA		Pre-clinical
Phico Therapeutics LtdSASPject™ PT53aOtherPrecise Pathogen ID
Priority Pathogen *
Serious E.coli infections where treatment options are limited		New Target
New MoA		Pre-clinical
Phico Therapeutics LtdSASPject™ PT3.83aOtherPrecise Pathogen ID
Priority Pathogen *
Serious Pseudomonas Aeruginosa infections where treatment options are limited		New Target
New MoA		Pre-clinical
Pherecydes PharmaPN17773aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Pseudomonas aeruginosa		New Class
New MoA		Pre-clinical
Pherecydes PharmaPN17923aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Pseudomonas aeruginosa		New Class
New MoA		Pre-clinical
Pherecydes PharmaPN17973aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Pseudomonas aeruginosa		New Class
New MoA		Pre-clinical
Pherecydes PharmaPN14933aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Staphylococcus aureus		New Class
New MoA		Pre-clinical
Pherecydes PharmaPN18153aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Staphylococcus aureus		New Class
New MoA		Pre-clinical
Pherecydes PharmaPN19573aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Staphylococcus aureus		New Class
New MoA		Pre-clinical
Pherecydes PharmaPN14503aPhagePrecise Pathogen ID
Priority Pathogen *
MDR infections to Pseudomonas aeruginosa		New Class
New MoA		Pre-clinical
BioNTech R&DPhM3983aPhagePrecise Pathogen ID
Priority Pathogen *
Periprosthetic Joint Infections		New Class
New MoA		Lead opt
BioNTech R&DPhM7543aPhagePrecise Pathogen ID
Priority Pathogen *
Urinary Tract Infections		New Class
New MoA		Lead opt
Omnix MedicalOMN63aProtein/PeptideGram -
Priority Pathogen *
A. baumannii induced Bacteremia or HABP or VABP		New Class
New MoA		Lead opt
NovaBiotics LtdNovamycin®3aProtein/PeptideNon Bacterial Target
Priority Pathogen *
Invasive Fungal Disease, mucocutaneous fungal infections		New Class
New Target
New MoA		Pre-clinical
NovaBiotics LtdNylexa™3dOtherBroad Gram +/-
Priority Pathogen *
Resistance breaker		New Class
New Target
New MoA		Pre-clinical
NovaBiotics LtdNovarifyn®3aProtein/PeptideBroad Gram +/-
Priority Pathogen *
Gram negative and Gram negative reistant/MDR infections (ESKAPE), some Gram positive coverage		New Class
New Target
New MoA		Pre-clinical
NovaBiotics LtdLuminaderm®1bProtein/PeptideBroad Gram +/-
Priority Pathogen *
MRSA		New Class
New Target
New MoA		Pre-clinical
NovaBiotics LtdLynovex® inhaled1aOtherBroad Gram +/-
Priority Pathogen *
Cystic Fibrosis		New Class
New Target
New MoA		IND/CTA ready
NovaBiotics LtdNovexatin®3aProtein/PeptideNon Bacterial Target
Priority Pathogen *
Onychomycosis		New Class
New Target
New MoA		Phase II
NovaBiotics LtdLynovex® oral3bOtherBroad Gram +/-
Priority Pathogen *
Cystic Fibrosis		New Class
New Target
New MoA		Phase II
NosopharmNOSO-2G3aNMEBroad Gram +/-
Priority Pathogen *
Hospitalacquired or Ventilatoracquired bacterial pneumoniae (HABP/VABP)		New Class
New Target
New MoA		Lead opt
NosopharmNOSO-5023aNMEGram -
Priority Pathogen *
Complicated urinary tract infections (cUTI)		New Class
New Target
New MoA		IND/CTA ready
Northern Antibiotics Oy (Ltd)NAB8153aProtein/PeptideGram -
Priority Pathogen *
cUTI caused by MDR Gram-negatives		Pre-clinical
Northern Antibiotics Oy (Ltd)NAB7393aProtein/PeptideGram -
Priority Pathogen *
cUTI caused by MDR Gram-negatives		Pre-clinical
Nabriva Therapeutics GmbHLefamulin3aNMEBroad Gram +/-
Priority Pathogen *
ABSSSI		New Class
New Target
New MoA		Phase II
Nabriva Therapeutics GmbHLefamulin3aNMEBroad Gram +/-
Priority Pathogen *
STIs, HABP/VABP, Osteomyelitis, Prosthetic Joint Infections		New Class
New Target
New MoA		Pre-clinical
Nabriva Therapeutics GmbHLefamulin3aNMEBroad Gram +/-
Priority Pathogen *
Pediatric Indications		New Class
New Target
New MoA		Phase I
Nabriva Therapeutics GmbHLefamulin3aNMEBroad Gram +/-
Priority Pathogen *
CABP (community-acquired bacterial pneumonia)		New Class
New Target
New MoA		Phase III
Mutabilis SAS2G-DABOCIN3aNMEGram -
Priority Pathogen *
IV treatment against Enterobacterales & non-fermenters		New ClassLead opt
Mutabilis SASEBL-14633aNMEGram -
Priority Pathogen *
IV treatment against Enterobacterales		New ClassPre-clinical
Madam Therapeutics BVSAAP1483aProtein/PeptideBroad Gram +/-
Priority Pathogen *
Diabetic foot ulcers, burns and MRSA carriership		New Class
New Target
New MoA		Pre-clinical
IMMUNETHEP, SAUnimab3cAntibodyBroad Gram +/-
Priority Pathogen *
Intensive Care Units / Hospital Acquired infections		New Class
New Target
New MoA		Pre-clinical
IMMUNETHEP, SAcPNV1aVaccineBroad Gram +/-
Priority Pathogen *
Preventive		New Class
New Target		Pre-clinical
Hypharm GmbHHY-1331bPhageGram +
Priority Pathogen *
Nasal colonization with MRSA		New Class
New Target
New MoA		Pre-clinical
Helperby Therapeutics LtdHY-0013dOtherGram -
Priority Pathogen *
Urinary Tract Infections		New Class
New Target
New MoA		Phase II
Helperby Therapeutics LtdHY-0023dOtherGram -
Priority Pathogen *
Intra-Abdominal Infections		New Class
New Target
New MoA		Phase I
Helperby Therapeutics LtdHY-0041bOtherGram +
Priority Pathogen *
Nasal MRSA decolonisation		New Class
New Target
New MoA		Phase II
Helperby Therapeutics LtdHY-0053dOtherGram +
Priority Pathogen *
Skin & Soft Tissue MRSA		New Class
New Target
New MoA		Phase II
Eligo BioscienceEB0041bOtherPrecise Pathogen ID
Priority Pathogen *
Multi-drug resistant Enterobacteriaceae		New Class
New MoA		Pre-clinical
Destiny Pharma plcXF-733dNMEBroad Gram +/-
Priority Pathogen *
Hospital pneumonia/ventilator-associated pneumonia (VAP)		New Class
New Target
New MoA		Pre-clinical
Destiny Pharma plcXF-701bNMEBroad Gram +/-
Priority Pathogen *
Bacterial biofilm-infections		New Class
New Target
New MoA		Pre-clinical
Destiny Pharma plcXF-731bNMEBroad Gram +/-
Priority Pathogen *
Prevention of post-surgical infection		New Class
New Target
New MoA		Phase II
DEINOVEDNV38373aNMEBroad Gram +/-
Priority Pathogen *
C.difficile gastrointestinal infections		New Class
New MoA		Phase II
Debiopharm InternationalDebio 14533aNMEGram -
Priority Pathogen *
N. gonorrhoeae infections		New Class
New Target
New MoA		Lead opt
Debiopharm InternationalAfabicin (Debio 1450)3aNMEPrecise Pathogen ID
Priority Pathogen *
ABSSSI, Bone & Joint Infections (BJIs)		New Class
New Target
New MoA		Phase II
Combioxin SACAL024aOtherBroad Gram +/-
Priority Pathogen *
Severe infections		New Class
New Target
New MoA		Phase II
Centauri Therapeutics LtdABX013cOtherGram -
Priority Pathogen *
Broad spectrum Gram negative, including clinically-relevant strains of Enterobacteriaceae, P. aeruginosa, and A. baumannii		New Class
New Target
New MoA		Pre-clinical
Centauri Therapeutics LtdABX023cOtherPrecise Pathogen ID
Priority Pathogen *
Pseudomonas Aeruginosa specific Inhibitor		New Class
New Target
New MoA		Pre-clinical
BioVersys AGBV2004aNMEGram +
Priority Pathogen *
Anti-toxin for Staphylococcus aureus		New Class
New Target
New MoA		Lead opt
BioVersys AGBV3003aNMEGram -
Priority Pathogen *
Hospital-acquired or Ventilator-acquired bacterial pneumoniae (HABP/VABP)		New Class
New Target
New MoA		Lead opt
BioVersys AGBVL-GSK0983dNMEPrecise Pathogen ID
Priority Pathogen *
Adjuvant reversing resistance and potentiating Ethionamide activity in Tuberculosis		New Class
New Target
New MoA		Phase I
BioFilm PharmaBFP0023eNMEBroad Gram +/-
Priority Pathogen *
Staphylococcus aureus, Pseudomonas aeruginosa Systemic – Cystic Fibrosis		New Target
New MoA		Lead opt
BioFilm PharmaBFP1013eNMEGram +
Priority Pathogen *
Staphylococcus aureus Local - Diabetic Foot Ulcer, Joint & Bone Infections		New Target
New MoA		Lead opt
BioFilm PharmaBFP1023eNMEBroad Gram +/-
Priority Pathogen *
Staphylococcus aureus, Pseudomonas aeruginosa Systemic – Cystic Fibrosis		New Class
New Target
New MoA		Lead opt
BioFilm PharmaBFP0013eNMEGram +
Priority Pathogen *
Staphylococcus aureus Local - Diabetic Foot Ulcer, Joint & Bone Infections		New Class
New Target
New MoA		Lead opt
BasileaCeftobiprole3aNMEBroad Gram +/-
Priority Pathogen *
Acute bacterial skin and skin structure infections, Staphylococcus aureus bacteremia		Phase III
BasileaCeftobiprole3aNMEBroad Gram +/-
Priority Pathogen *
Community- and hospital-acquired pneumonia (excluding ventilator-associated pneumonia)		Marketed
ANTABIO S.A.SANT_Pei3cNMEPrecise Pathogen ID
Priority Pathogen *
Pseudomonas infections in Cystic Fibrosis patients		New Class
New Target
New MoA		Pre-clinical
ANTABIO S.A.SANT26813dNMEGram -
Priority Pathogen *
Hospital-acquired infections caused by carbapenem-resistant Enterobacteriaceae (CRE) [cUTI, cIAI, Nosocomial Pneumonia]		New Class
New Target
New MoA		Pre-clinical
AlphanososW16P05763eOtherBroad Gram +/-
Priority Pathogen *
A. baumannii, P. aeruginosa, MRSA,N. gonorrhoeae, M. tuberculosis - Infectious skin conditions (eczema, acne, sporiasis, ...), difficult wounds		New Class
New Target
New MoA		Pre-clinical
ALLECRA THERAPEUTICSCefepime / Enmetazobactam3dNMEBroad Gram +/-
Priority Pathogen *
cUTI, cIAI, HAP		Phase II
AktheliaHO53/HO56 ADP3cNMEBroad Gram +/-
Priority Pathogen *
Multidrug resistant lung infections including nosocomial infections (K. pneumoniae)		New Class
New Target
New MoA		Lead opt
AiCuris Anti-infective Cures AGArtilysins3aProtein/PeptideGram -
Priority Pathogen *
Undisclosed		New Class
New MoA		Lead opt
AGILeBiotics B.V.ABX-3953aNMEGram -
Priority Pathogen *
Hospital-treated MDR Gram-negative infections		Lead opt
AGILeBiotics B.V.ABX-605 (Toframicin)3aNMEGram -
Priority Pathogen *
Hospital-treated MDR Gram-negative infections		Pre-clinical
ABAC therapeuticsABAC-39,8773aNMEGram -
Priority Pathogen *
Infections by MDR/XDR A baumannii, including ColistinR and CarbapenemR		New Class
New Target
New MoA		Pre-clinical
Da VolterraDAV1214bOtherBroad Gram +/-
Priority Pathogen *
Prevention of gut microbiota antibiotic-dysbiosis and emergence of resistance to β-lactam antibiotics, including carbapenems		New Class
New Target
New MoA		Lead opt
Da VolterraDAV1324bOtherBroad Gram +/-
Priority Pathogen *
Prevention of C.difficile infections		New Class
New Target
New MoA		Phase II
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*Priority pathogens have been listed by WHO and CDC

The displayed information are not necessarily reflecting the official current position of each BEAM members; please refer to each company’s website for updated information, or contact them directly.

Pipeline Dx

Click on column headers to sort the table

memberkit/testtargeted resultpathogens & indicationslab workflowdevelopment stage
MDI-MICAST PhenotypingIncl. Priority Pathogens
Escherichia coli - Enterobacter Pseudomonas - Acinetobacter
Standard MIC determination for multi-resistant strains and new therapeutic strategies 		From isolated colony
Microfluidic liquid handling
<8h		Feasibility Phase
MDI-SepsisID/AST combinedIncl. Priority Pathogens
Escherichia coli - Klebsiella - Enterobacter - Proteus - Pseudomonas - Haemophilus - Acinetobacter - Staphylococcus - Streptococcus - Candida
Sepsis		From whole blood
Microfluidic liquid handling
<24h		Feasibility Phase
BioFilm PharmaAntiBiofilmogram Urinary CareAST PhenotypingIncl. Priority Pathogens
E. coli
Urinary Tract Infections, Catheter Associated Urinary Tract Infections		From isolated colony
Microplate-reader
<4h		Development Phase
BioFilm PharmaAntiBiofilmogram Lung CareAST PhenotypingIncl. Priority Pathogens
Staphylococcus aureus
Cystic Fibrosis		From isolated colony
Microplate-reader
<4h		Prototype in Lab
BioFilm PharmaAntiBiofilmogram Lung CareAST PhenotypingIncl. Priority Pathogens
Pseudomonas aeruginosa
Cystic Fibrosis		From isolated colony
Microplate-reader
<4h		Prototype in Lab
BioFilm PharmaAntiBiofilmogram Wound CareAST PhenotypingIncl. Priority Pathogens
Staphylococcus aureus
Diabetic Foot Ulcer, Joint & Bone Infections		From isolated colony
Microplate-reader
<4h		Clinical Validation EU and/or US
MeMed Diagnostics Ltd.MeMed BV™Viral vs Bacterial 
 
Point-of-need discrimination of the viral/bacterial nature of an infection		From serum/plasma
 
<30 minutes		Clinical Validation EU and/or US
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The displayed information are not necessarily reflecting the official current position of each BEAM members; please refer to each company’s website for updated information, or contact them directly.