Aberdeen, August 24, 2021. NovaBiotics Ltd, a privately held clinical stage company developing novel immune based therapies for life-threatening and life-limiting diseases, announces that Deborah O’Neil, Ph.D., Chief Executive Officer of NovaBiotics, delivered a presentation highlighting NovaBiotics’ novel peptide drug candidates at the Peptide Therapeutics Forum 2021 that took place August 19-20, 2021, in Basel, Switzerland. The event featured presentations that provided exciting new insights into peptide therapeutics.
In her presentation titled, “Novel peptide therapy candidates for medically unmet fungal and bacterial infections,” Dr. O’Neil focused her discussion on NovaBiotics’ novel antifungal and antibacterial therapy candidates that the Company generated from its proprietary cationic antimicrobial peptide technology platform.
The presentation highlighted NP339, a 2 kDa linear fungicidal peptide comprising basic, polar residues and is active against moulds and yeasts including Aspergillus fumigatusi and NP432, a linear 2kDa bactericidal peptide comprising both polar and nonpolar, aromatic residues and has activity against Gram-negative and some Gram-positive bacteria including Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus. “Faced with a next pandemic of antimicrobial resistance, the need for new classes of safe and effective antimicrobials has never been more acute. Immune-based, non-antibiotic antimicrobial strategies, such as NovaBiotics’ peptides, have manifold therapeutic advantages over microbiological approaches to combatting infection and existing antifungal and antibacterial therapy classes. These include rapid microbicidal mechanism of action, agnosticism to metabolic and drug-resistance status of the target pathogen and specificity which circumvents off-target pharmacology,” stated Dr. O’Neil in her presentation.
“NovaBiotics is developing proprietary compounds based on the body’s innate immune effector molecules to advance a truly revolutionary approach to combatting life-threatening and life-limiting diseases. We believe these compounds, including our peptides, represent promising new classes of therapy with novel modalities and the potential to transform treatment paradigms in a number of poorly served diseases,” added Dr. O’Neil.
Full PR available 2021.08.24 NovaBiotics Peptide Tx Forum Wrap Up.