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National Burden of Macrolide-Resistant Streptococcus Pneumoniae in the United States From Blood and Respiratory Tract Cultures Approaches 40 Percent

May 18, 2020 at 8:00 AM EDT

Large, contemporary, cross-sectional study highlights the urgent need for local epidemiology data to be available to inform empiric antibiotic choices that are concordant with the IDSA/ATS community-acquired pneumonia (CAP) guidelines

DUBLIN, Ireland, May 18, 2020 (GLOBE NEWSWIRE) — Nabriva Therapeutics plc (NASDAQ: NBRV), a biopharmaceutical company engaged in the commercialization and development of innovative anti-infective agents to treat serious infections, announced the publication of a study entitled, A Multicenter Evaluation of the U.S. Prevalence and Regional Variation in Macrolide Resistant S. pneumoniae from Blood or Respiratory Cultures among Adult Patients (Abstract #5523), online in the proceedings of 30thEuropean Congress on Clinical Microbiology and Infectious Diseases (ECCMID).

This study assessed 3,510 patients with a positive S. pneumoniae blood or respiratory culture in the ambulatory and inpatient setting at 329 hospitals across nine U.S. Census geographic regions over 12 months ending 3Q2019 to determine the prevalence and rates of macrolide resistance in S. pneumoniae. Macrolide resistance was observed in 47.3 percent of S. pneumoniae obtained from respiratory cultures, and 29.6 percent from blood cultures. Higher rates of macrolide resistance were seen among ambulatory patients (45.3 percent) as compared with inpatients (37.8 percent). While the overall rate of macrolide resistance was 39.5 percent, regional variation occurred, ranging from 13.9 percent in the Mountain region to 54.2 percent in the West North Central region, demonstrating the importance of local epidemiology data to inform selection of empiric therapy for patients with community-acquired bacterial pneumonia (CABP).

“These results are a stark reminder of the urgent need for innovative antibacterial agents with a new mechanism of action to address the growing public health threat of antibiotic resistance,” said Jennifer Schranz, MD, Chief Medical Officer at Nabriva. “S. pneumoniae has been designated as a serious threat by the CDC, and the high rates of macrolide resistant S. pneumoniae from respiratory and blood isolates throughout the United States highlight the urgent need for timely epidemiology information to be readily available so that physicians can make evidence-based decisions about empiric antibiotic therapy for patients with CABP.”

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