High-Performance Genome Annotation for a Safer and Faster-Developing Phage Therapy

This article is dealing with phage genome annotation and its impact on phage therapy. Our study compares manual annotation (SEA-PHAGES) with our own pipeline. The comparison showed that :

• Manual annotation remains slightly better for structural annotation (gene-calling), but has minimal impact on functional annotation
• rTOOLS outperforms in functional annotation.
• Overall, the results are very similar : rTOOLS is the first automated pipeline to match human expert-level performance in phage genome annotation.

Full article available here