Fungal Update Meeting 2019: First Case Report of PC945 Treatment of Refectory Aspergillus Anastomotic Infection in a Lung Transplant Recipient
A team from the Royal Brompton/Harefield NHS Trust presented the first case report of the inhaled anti-fungal PC945, at the Fungal Update meeting held in London on 15th-16th March, 2019.
This report described a case in which PC945 was used to treat an Aspergillus bronchial anastomotic infection and tracheobronchitis in a patient who had undergone a lung transplant for cystic fibrosis. The infection had been refectory to months of treatment with posaconazole, terbinafine and nebulised amphotericin B.
When endobronchial examination was performed after 8 weeks of PC945 treatment, mucosal erythema had resolved and the fungal mass had cleared from the anastomosis. No adverse reactions were reported and the patient reported that it was easy to tolerate the PC945 nebulisations.
The abstract is available here