In a new publication, the company’s flagship compound proves effective in targeting the harmful pathogen while preserving a healthy microbiome
Zug, Switzerland, 14 April 2022 — Micreos Pharmaceuticals today announces findings from a study proving the effectiveness of XZ.700, a novel antibacterial enzyme, in selectively targeting and killing the harmful Staphylococcus aureus bacterial pathogen while maintaining a healthy microbiome and preventing antimicrobial resistance (AMR). XZ.700 is the first of many innovative endolysins in the Micreos Pharmaceuticals portfolio and is critically important as the first molecule the company will bring to market. The findings were published in Antimicrobial Agents and Chemotherapy.
S. aureus is a pathogen associated with causing and aggravating a wide spectrum of conditions, ranging from mild disorders to life-threatening disease. These infections can be difficult to treat because S. aureus can hide in niches within the body, and it readily develops resistance to antibiotics. To date, there is no pharmaceutical treatment available that specifically targets S. aureus, thereby relieving symptoms while keeping the healthy skin microbiota intact.
XZ.700 is a novel antibacterial enzyme which effectively kills S. aureus without harming closely related and beneficial organisms, such as Staphylococcus epidermidis, which is part of the normal human skin microflora. Researchers from Micreos and ETH Zurich designed XZ.700 by combining elements from a bacteriophage endolysin and a S. aureus-specific bacteriocin, both agents that naturally target bacteria. They found that XZ.700 selectively removes S. aureus from a simplified skin microbiome and is effective against S. aureus on reconstituted human skin and in a mouse model of a S. aureus-induced skin infection. Importantly, no resistance emerged in S. aureus when it was repeatedly exposed to XZ.700 – a critical feature amidst the soaring AMR crisis.
“I am proud to see how developments at Micreos that are based on fundamental research conducted in our lab at ETH are now progressing into medical applications to help patients with inflammatory skin conditions,” said Professor Martin Loessner of ETH Zurich, a leading researcher and co-author of the paper.
“XZ.700 forms one of the main building blocks of our endolysin portfolio and is the starting point for many more molecules to come,” said PD Dr. Mathias Schmelcher, Chief Scientific Officer at Micreos Pharmaceuticals, and co-author of the research. “With our technology, we have the possibility to selectively target the pathogen S. aureus while preserving a healthy skin microbiome. This could revolutionise the way we treat inflammatory skin disorders with an infectious component in the future.”
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